Sodium phosphate tribasic dodecahydrate was used to prepare buffer solution used in the analysis of pyronaridine in human whole blood and plasma by using high-performance liquid chromatography.

Sodium phosphate tribasic also referred to as Trisodium phosphate or TSP is a widely used cleaning agent. Trisodium phosphate disrupts cytoplasmic as well as outer membranes of Salmonella enterica cells and hence prevents the spread of bacteria. Further, it is corrosion inhibitor for iron and inhibits the rate of the anodic iron dissolution reaction in unbuffered solutions.