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Guanidine Hydrochloride is a potent protein denaturant extensively utilized in the purification of proteins and nucleic acids. Widely recognized for its versatility, it plays a pivotal role in total RNA extraction experiments, dissolving proteins and disrupting cell structures while inactivating RNA enzymes.
biological source
synthetic (organic)
Quality Level
Assay
≥99% (titration)
form
crystalline powder
technique(s)
RNA extraction: suitable
impurities
≤0.3% water (Karl Fischer)
color
white
pH
(25 °C, 4.6 - 6 at 573 g/L)
mp
180-185 °C (lit.)
solubility
H2O: 6 M
density
1.3 g/cm3 (lit.)
absorption
≤0.10 at 260 nm in H2O at 6 M
SMILES string
Cl[H].NC(N)=N
InChI
1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
InChI key
PJJJBBJSCAKJQF-UHFFFAOYSA-N
Rp 1.534.000
Rp 3.250.000
Rp 2.197.000
Rp 2.057.000
Rp 5.089.000
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