4-Amino-3-hydroxy-1-naphthalenesulfonic acid is an aromatic amino-sulfonic acid.

4-Amino-3-hydroxy-1-naphthalenesulfonic acid has been used to study separation of aromatic sulfonated compounds using Ion-interaction high-performance liquid chromatography and micellar electrokinetic capillary chromatography techniques. It has also been used as a starting material which when reacted with palmitoyl chloride yields the following derivatives:

2′-Pentadecylnaphth[3,4-d]oxazole-1-sulfonic acid

4-Amino-3-(palmitoyloxy)-1-naphthalenesufonic acid

4-(Palmitoylamino)-3-hydroxy-1-naphthalenesulfonic acid

4-(Palmitoylamino)-3-(palmitoyloxy)-1-naphthalenesulfonic acid